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mreBH [2017-02-27 15:02:04]
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mreBH [2017-02-27 15:02:04]

cell shape-determining protein, forms filaments, the polymers control/restrict the mobility of the cell wall elongation enzyme complex, required for LytE activity
locus
BSU14470
pI
5.00
mw
35.00 kDa
protein length
335 aa Sequence Blast
gene length
1005 bp Sequence Blast
function
cell shape determation
product
cell shape-determining protein
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.2|Cell shape]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|SigI regulon], [SW|WalR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,516,574 -> 1,517,581

    The protein

    Catalyzed reaction/ biological activity

  • forms ring-shaped filaments in a heterologous system [Pubmed|21091501]
  • required for the activity of [protein|321F248C22D7283C0F3323F1F4069E36F8D7FE6C|LytE] [Pubmed|23869552,16950129]

    • Protein family

  • ftsA/mreB family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|A4C8719E06F774A6EB4D79757CC79CF89E453A54|MreB], [protein|6ED386D49F973C1F6B1076974F54275DD583C9D3|Mbl]

    • Structure

  • [PDB|1JCF] ([protein|A4C8719E06F774A6EB4D79757CC79CF89E453A54|MreB] from ''Thermotoga maritima'', 52% identity) [Pubmed|11544518]

    • [SW|Localization]

  • during logarithmic growth, [protein|40829C3632E9DCEB9E1C14A674B4B217F504CFE0|MreBH] forms discrete patches thst move processively along peripheral tracks perpendicular to the cell axis [Pubmed|21636744]
  • forms transverse bands as cells enter the stationary phase [Pubmed|21636744]
  • close to the inner surface of the cytoplasmic membrane [Pubmed|16950129]
  • reports on helical structures formed by MreBH [Pubmed|16950129,20566861] seem to be misinterpretation of data [Pubmed|21636744]
  • normal localization depends on the presence of glucolipids, [protein|A4C8719E06F774A6EB4D79757CC79CF89E453A54|MreB] forms irregular clusters in an ''[gene|7A606B8E952AE8CA4F9A62008BA4B156725BB5B5|ugtP]'' mutant [Pubmed|22362028]
    • Expression and Regulation
    [[this]]

    References

    Localization

  • 17064365,20566861,21636744,21636745,22362028

    • Other original publications

  • 16950129,19643765,16950129,18156261,19659933,21091501,22069484,23879732,23869552,24125693,11544518